Search results for "alpha-Melanocyte-stimulating hormone"

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Betulin binds to melanocortin receptors and antagonizes alpha-melanocyte stimulating hormone induced cAMP generation in mouse melanoma cells.

2007

Betulin is a principal component of birch bark and is known to possess a broad range of biological activities, including antiinflammatory, antiviral and anticancer actions. The present study was carried out in vitro to clarify the influence of betulin on melanocortin (MC) receptor-ergic signalling by using COS-7 cells transfected with corresponding human MC receptor DNA. The results showed that betulin binds to the human melanocortin MC1, three to five receptors with selectivity to the MC1 subtype (K(i) value 1.022 +/- 0.115 microM). Betulin binds to the MC receptors with the following potency order-MC > MC3 > MC5 > MC4. Betulin itself does not stimulate cAMP generation, however, it slightl…

Clinical BiochemistryBiologyBiochemistryBinding Competitivechemistry.chemical_compoundMiceBetulinic acidChlorocebus aethiopsCyclic AMPAnimalsHumansReceptorMelanomaBetulinReceptors MelanocortinCell BiologyGeneral MedicineTransfectionIn vitroalpha-Melanocyte-stimulating hormoneTriterpenesKineticsBiochemistrychemistryCell culturealpha-MSHCOS CellsMelanocortinCell biochemistry and function

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